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Sildenafil is a potent and selective inhibitor of cGMP specific phosphodiesterase kind 5 (PDE5) while in the corpus cavernosum, in which PDE5 is liable for degradation of cGMP. Sildenafil provides a peripheral site of action on erections. Sildenafil has no direct relaxant effect on isolated human corpus cavernosum but potently enhances the relaxant